Laboratory of Functional Lipidomics and Metabolic Regulation
School of Life Sciences
Principal Investigator: Yilong Zou 邹贻龙, Ph.D.
PUBLICATIONS
23. Wang F*, Graham ET*, Naowarojna N*, Shi Z*, Wang Y, Xie G, Zhou L, Salmon W, Jia J, Wang X, Huang Y, Schreiber SL#, Zou Y#. PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ. Cell Chemical Biology 2021 doi: 10.1016/j.chembiol.2021.11.001 (*co-first author, #co-corresponding author)
20. Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020.
19. Zou Y*,#, Henry WS*, Ricq EL*, Graham ET, Maretich P, Paradkar S, Phadnis VV, Boehnke N, Deik AA, Reinhardt F, Eaton JK, Ferguson B, Wang W, Fairman J, Keys H, Dančík V, Clish CB, Clemons PA, Hammond PT, Boyer LA, Weinberg RA#, and Schreiber SL#. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature 2020 Sep 16. doi: 10.1038/s41586-020-2732-8. (*co-first author, #co-corresponding author)
18. Zou Y* & Schreiber SL*. Progress in understanding ferroptosis and challenges in its targeting for therapeutic benefit. Cell Chemical Biology 2020 April; 27(4): 463-471. (Perspective) (*co-corresponding author).
https://doi.org/10.1016/j.chembiol.2020.03.015
17. Zou Y*,#, Li H*, Graham ET, Deik AA, Eaton JK, Wang, Sandoval-Gomez G, Clish, Doench JG, & Schreiber SL#. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nature Chemical Biology 2020 Mar;16(3):302-309. PMID: 32080622.
(*co-first author, #co-corresponding author)
16. Aragón A*, Wang Q*, Zou Y*, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Márquez JA, Hadjantonakis A-K, Macias MJ, and Massagué J. Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer directed TGF-β signaling. Genes&Development 2019 Nov 1;33(21-22):1506-1524. doi:10.1101/gad.330837.119. (*co-first author, listed in alphabetical order.)
15. Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik AA, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, Barretina J, Pagliarini RA, Galli GG, Root DE, Hahn WC, Tsherniak A, Giannakis M, Schreiber SL, Clish CB, Garraway LA, and Sellers WR. The landscape of cancer cell line metabolism. Nature Medicine 2019 May;25(5):850-860. PMID: 31068703.
14. Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng Y-Y, Deasy R, Alimova M, Dančik V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench J, Clish CB, Clemons PA, and Schreiber SL. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nature Communications 2019 Apr 8;10(1):1617. PMID: 30962421. doi: https://doi.org/10.1038/s41467-019-09277-9
11. Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragon E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Marquez JA, Massagué J and Macias M. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nature Communications 2017 Dec 12; 8(1):2070. PMID: 29234012.
9. Wang Q*, Zou Y*, Nowotschin S, Li Q, Soh C-L, Kim SY, Xi Q, Zhang C, Su J, Shu W, Huangfu D, Hadjantonakis A-K and Massagué J. The p53 family coordinates Wnt and Nodal Inputs for mesendoderm differentiation of embryonic stem cells. Cell Stem Cell 2017 Jan 5;20(1):70-86.
https://doi.org/10.1016/j.stem.2016.10.002. PMID: 27889317.
(*Co-first author)
3. Morris LG, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan Ş, Eng S, Kannan K, Zou Y, Peng L, Banuchi VE, Paty P, Zeng Z, Vakiani E, Solit D, Singh B, Ganly I, Liau L, Cloughesy TC, Mischel PS, Mellinghoff IK and Chan TA. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nature Genetics. 2013 Mar;45(3):253-61. PMID: 23354438.